Cardarineis a chemical developed by GlaxoSmithKline and Ligand Pharmaceuticals. The chemical was studied for treating hyperlipidemia, diabetes and heart diseases, but research was halted in phase 2 when intestinal adenoma was observed in mice due to this chemical. However, a later study showed that higher doses of Cardarineenhanced the physical performance of rats. Cardarine is now taken to increase fat burning, build muscles, reduce obesity and treat cardiovascular diseases and lipid disorders.
Mechanism of action
Cardarine or gw 50156 is a selective agonist for Peroxisome Proliferator Activator Receptor Delta. PPAR Delta is a sensor protein for fat metabolism present in adipose tissue, liver, brain and skeletal muscles. Cardarine regulates fatty acid oxidation by activating PPAR Delta. As a result, the rate of fat burning increases. Activation of PPAR Delta by Cardarine also increases lipid catabolism in skeletal muscles. Research has shown that Cardarinedecreases fat levels in the blood by 10-30%. This drug also decreases fat in the liver and insulin levels.
Cardarine activates PPR Delta and does not attach directly with androgen receptors in bones and muscles. Thus, Cardarine is not a Selective Androgen Receptor Modulator.
Benefits of Cardarine
Fat burning is a significant benefit of cardarine. It is a PPAR Delta agonist which causes the body to burn extra fat rapidly. The skeletal muscles burn stored fat, but the muscle mass is preserved. Thus, you lose excess fat while retaining strength due to intact muscles.
Cardiovascular endurance is improved significantly by cardarine. This is because the drug causes the muscles to take more oxygen from the blood—consequently, the ability of your body to perform intense physical workouts without getting fatigued increases. A study found that Cardarine increases the distance run by mice, thereby indicating increased cardiovascular endurance.
Cardarine increases muscle growth. PPAR Delta activated by cardarinenot only burns fat but also stimulates the growth of muscle fibres. Thus, cardarine adds to the existing muscle mass of the body.
Cardarineincreases blood flow through the vessels. Thus, it improves the heart and brain functions. In addition, cardarine also protects the walls of blood vessels due to its anti-inflammatory action. So, it decreases the uncertainty of myocardial damage.
Cardarinedoes not negatively affect the male hormone testosterone. Thus, PCT is not required to use cardarine. Testosterone hormone is necessary to develop testes and other reproductive organs and secondary sexual characteristics such as hair growth on the body and an expansion in muscle and bone mass.
Cardarine promotes wound healing by activating the PPAR Delta pathway. PPAR Delta has a vital role in the wound healing process because it causes fibroblast differentiation to myofibroblast.
Cardarine increases the synthesis of antioxidant enzymes, which protect the cells against damage. It also improves the functions of the liver and kidneys.
Side effects of Cardarine
Cardarine causes the liver to convert fat instead of glucose into energy and maintains proper sugar levels in the body. However, an excess dosage of cardarine causes the death of liver cells, leading to liver damage.
Excessive consumption of cardarine can result in the formation of cancerous tumours. Studies have shown that cardarine has the potential to cause many types of cancer if taken in excess. Expecting women should not use this drug because it impairs the growth of the foetus.
Excess consumption can also lead to impairment of cardiac health and damage the reproductive system.
To sidestep the side effects, it is essential to take the correct dosage. The safest range of dosage as determined by animal studies is 10-20 mg per day. As per experts, 10 mg per day should be the dosage for beginners. However, as you become experienced in taking this drug, the dosage can be gradually increased to 20 mg per day. But the daily dosage should never exceed 20 mg.
The half-life of cardarine is 12-24 hours. Hence, to avoid excessive drug levels in your body, the 10/20 mg dosage should be divided into two doses in a day. Division should be in equal parts, such as 5mg or 10 mg twice a day. The cycle should not be more than 8-12 weeks. Exceeding the drug cycle beyond 12 weeks increases the risk of dangerous side effects. Limited dosage within the recommended process provides maximum benefits without side effects.
How to purchase?
There are many online pharmacies offering cardarine for sale. Cardarine can be purchased from such stores with or without prescription except in Australia, where this drug is banned. The drug has not received FDA approval and is classified as a research chemical, but there is no bar on sales for human consumption.