Melanotan I (afamelanotide) is a synthetic melanocyte-stimulating hormone (a-MSH) that promotes skin pigmentation by inducing melanogenesis or the synthesis of melanin. Melanotan I is used to treating acne and other skin conditions. Melanin protects the skin’s cells from harm caused by light by absorbing, reflecting, and refracting it. Melanotan I prevents sun damage to UV-exposed skin by causing cells to generate dark protective melanin, which helps to protect the skin from further harm.
Introduction
Formula: C78H111N21O19
Structure: Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
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Usage of Melanotan I
Melanotan I is a medication that is used to reduce phototoxicity in individuals who have erythropoietic protoporphyria, that is, a lack of the enzyme ferrochelatase. Melanotan I is a photoprotective agent. People who suffer from this condition feel discomfort when their epidermis is exposed to the sun or certain artificial lights. Because of unusually low quantities of this enzyme in the blood plasma and red blood cells, high quantities of protoporphyrin accumulate in the bone marrow, plasma, and red blood cells.
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Melanotan I (Melanotan) is a topical drug that is used to improve skin tanning in certain light-related skin indications, as a preventive therapy for a variety of light-related skin diseases, and as a possible skin cancer prevention agent.
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The underlying mechanism of action when it comes to Melanotan I
Injecting Melanotan I into the body causes the body to produce more alpha-melanocyte-stimulating hormone than it needs. The alpha-melanocyte-stimulating hormone attaches to melanocortin receptors on the surface of skin cells, causing them to produce the pigment melanin. As a result, the greater the amount of melanin produced by the skin cells, the deeper the skin will look.
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Melanotan I seems to be more stable in the organism than Melanotan II, which means it may last longer before being degraded by enzymes. While Melanotan II has a greater number of receptors than Melanotan I, it has a shorter half-life in the body than Melanotan I.
Symptoms and Consequences of using Melanotan I
The fact that tanning injections are not regulated is the most serious source of worry. The use of a product that has not been properly labeled cannot be guaranteed in the absence of appropriate regulations. Furthermore, the long-term consequences of Melanotan I are mostly unclear.
Nutrient-induced nausea and vomiting, skin flushing, and lack of appetite, as well as sleepiness and exhaustion, are the most frequent adverse effects of Melanotan I. These symptoms are generally transient.
The most important advantages of using Melanotan I
- Melanotan 1 may be used safely in conjunction with UV-B light or sunshine, and it seems to work in a synergistic manner to enhance the tanning reaction.
- Reduce exposure to UV radiation, which may be found in sunshine, and the lamps used during interior tanning beds, which reduces the chance of developing skin cancer or other skin problems.
- Melanotan I may be used to darken and tan the tone of the skin if this is desired.
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